Brain Stem MRI Signal Abnormalities in CADASIL

Brain stem MRI signal abnormalities in CADASIL.

BACKGROUND We recently showed that the severity of MRI signal abnormalities increases with age in CADASIL, an arteriopathy due to mutations of notch 3 gene on chromosome 19. Previous results also suggest that the various hemispheric subcortical areas have a different vulnerability to ischemia in this disease. The distribution of the lesions at the brain stem level has not yet been reported. C...

Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy.

PURPOSE To assess the reproducibility and accuracy compared to radiologists of three automated segmentation pipelines for quantitative magnetic resonance imaging (MRI) measurement of brain white matter signal abnormalities (WMSA). MATERIALS AND METHODS WMSA segmentation was performed on pairs of whole brain scans from 20 patients with multiple sclerosis (MS) and 10 older subjects who were pos...

Brain abnormalities in fetuses: in-utero MRI versus ultrasound

Prenatal imaging for diagnosis and prediction of neurodevelopmental outcomes in fetuses with brain malformations is a substantial challenge. Accurate diagnosis of brain abnormalities has important therapeutic implications. Consequently, it is essential that tools used for prenatal diagnosis are rigorously evaluated. The standard of care is prenatal ultrasound, but in-utero MRI (iuMRI) has been ...

Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL.

BACKGROUND Migraine with aura (MA) is one of the clinical hallmarks of CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a small vessel disease of the brain caused by mutations in the NOTCH3 gene, but its exact mechanisms are unknown. OBJECTIVES To describe the patterns of MA in CADASIL and to compare brain magnetic resonance signal abnormal...

Brain MRI Findings in Tramadol Poisoning